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Venkata Ramana Reddy, K.
- Molecular Aspects of BBB
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1 Dept. of Pharmaceutics, Sree Dattha College of Pharmacy, R.R. Dt., Andhra Pradesh, IN
2 Dept. of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt. A.P, IN
1 Dept. of Pharmaceutics, Sree Dattha College of Pharmacy, R.R. Dt., Andhra Pradesh, IN
2 Dept. of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt. A.P, IN
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Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 2 (2014), Pagination: 105-109Abstract
The function of the BBB is dynamically regulated by various cells present at the level of the BBB. This realization implies better understanding of the relationship of at the BBB to drug structure and physicochemical properties. The physical barrier naming BBB is characterized by tight junctions between endothelial cells, by the absence of fenestrations and low occurrence of pinocytic activity 1.Penetration of chemicals to the BBB occurs using a combination of intra and intercellular passages. The main factors that limit the penetration of lipophilic membranes by any molecule are its molecular weight and its ability to form hydrogen bonds and so bind to circulating plasma proteins. Tight junctions regulate the intracellular passage of molecules according to their physico-chemical properties (e.g. lipophilicity, ionization and polarity), where inter cellular penetration is regulated by influx and efflux transporters, endocytosis and passive diffusion.Keywords
Pharmacokinetic and Pharmacodynamic Parameters Affecting BBB. Fundamental Principles.- Pharmaceutical Excipients- Their Mechanisms
Abstract Views :171 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam. Ranga Reddy, District Andhra Pradesh -506501, IN
2 Department of Pharmaceutics, Sree Dattha College of Pharmacy, R.R., Dt., A.P, IN
3 Department of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt., A.P, IN
4 Department of Pharmaceutics, Sree Dattha College of Pharmacy, R.R., Dt., Andhra Pradesh, IN
1 Department of Pharmaceutics, Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam. Ranga Reddy, District Andhra Pradesh -506501, IN
2 Department of Pharmaceutics, Sree Dattha College of Pharmacy, R.R., Dt., A.P, IN
3 Department of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt., A.P, IN
4 Department of Pharmaceutics, Sree Dattha College of Pharmacy, R.R., Dt., Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 6 (2013), Pagination: 355-360Abstract
Additives are non drug component for structuring dosage form and said to be pharmacologically inactive in nature. Selections of excipients were depend upon type of dosage form, their functionality and based on their compatible atmosphere with respect to the active and inactive ingredients and method of preparation. Their role is vital and forming back bone of type of dosage form including solid, semi-solid and liquid dosage form used for topical and conventional application. To turn a drug (API) substance into a desired pharmaceutical dosage form or a drug delivery system, pharmaceutical ingredients were required. Majority of times formulation stability and their bioavailability depends upon selection of excipients and their concentration level with combinations. The peer knowledge of current review article enlists the different mechanisms of various additives used in multi formulations with their ultimate mechanism role in-depth basics and their background knowledge in designing of various dosage formulations.- Super Porous Hydrogels
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Authors
Affiliations
1 Dept. of Pharmaceutics, NNR College of Pharmacy, Himayath Nagar, R.R. Telangana State, -501512, IN
2 Dept. of Pharmaceutics, KVK College of Pharmacy, Hayath Nagar, R.R. Telangana State, -501510, IN
3 Dept. of Pharmaceutics, Anurag Group of Institutions, Medchal, Telangana State, 501510, IN
1 Dept. of Pharmaceutics, NNR College of Pharmacy, Himayath Nagar, R.R. Telangana State, -501512, IN
2 Dept. of Pharmaceutics, KVK College of Pharmacy, Hayath Nagar, R.R. Telangana State, -501510, IN
3 Dept. of Pharmaceutics, Anurag Group of Institutions, Medchal, Telangana State, 501510, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 434-442Abstract
Super porous hydrogel (SPH) swells very rapidly in a shorter period of time (due to the presence of interconnected microscopic pores) to an equilibrium size and contains highly porous structure. Hydrogels are they are water insoluble. The swelling properties of hydrogels are mainly related to the network elasticity, the presence of hydrophilic functional groups, the cross-link density, and porosity. The first approach for SPH synthesis involves cross-linking of co-monomers using multifunctional co-monomer, which acts as cross-linking agent. They maintain their integrity in the harsh stomach environment, while releasing the pharmaceutical active ingredient. The fast swelling property is based on water absorption through open porous structure by capillary force. The retention of the dosage form in the stomach prolongs overall GI transit time, thus resulting in improved oral bioavailability of the drug. Because these hydrogels absorb a large volume of environmental fluids, which expand their volume considerably over a very short time, their sheer bulk hinders their transport to the next organ via the narrow pylorus. This unique swelling property allows them to be used as gastric retention carriers, providing sustained release through long/maximium residence in the stomach region.Keywords
Super Porous Hydrogels and Their Generations. Gastric Retention Technology.References
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